These few missions play out a bit like a tutorial, so once they’re finished you’ll be able to put your wicked imagination to creative use and start whipping up new experiments to unleash on your residents. While you can get into Vault 88 right away - and you can access some pretty sweet goodies right off the bat without even a Science check - unlocking the more dastardly hobbies that define Bethesda’s evil vault company take a few fetch quests in order to get them set up. I won’t spoil the journey for you, but suffice it to say that in spite of its brevity it’s still worth paying attention to. There’s a short period of question and answer before you happen upon the perfect idiot.
Once you’ve completed clearing out the Vault’s tunnels (which are expansive), you can set about interviewing potential guinea pigs.